KETOFEN
4A SANTE
Identification
- Active ingredient (INN)
- KETOPROFENE
- Internal code
- 21 A 032
- Country of Origin
- Algeria
- Pharmaceutical form
- Dermal Gel
- Prescription List
- Regulated (List II)
- Packaging
- T/60G
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications
For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Pharmacodynamics
Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis.
Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.
Mechanism of Action
G/H synthase 2 Inhibitor Prostaglandin G/H synthase 1 Inhibitor C-X-C chemokine receptor type 1 Other.
Absorption
Ketoprofen is rapidly and well-absorbed
Oral, with peak plasma levels occurring within 0.5-2 hours.
Metabolism
Rapidly and extensively metabolized in the liver, primarily via conjugation to glucuronic acid.
No active metabolites have been identified.
Hover over products below to view reaction partners Ketoprofen Ketoprofen glucuronide.
Route of Elimination
In a 24 hour period, approximately 80% of an administered dose of ketoprofen is excreted in the urine, primarily as the glucuronide metabolite.
Half-life
Conventional capsules: 1.1-4 hours Extended release capsules: 5.4 hours due to delayed absorption (intrinsic clearance is same as conventional capsules).
Clearance
Oral-dose cl=6.9 +/.
- 0.8 L/h Oral-dose cl=6.8 +/.
- 1.8 L/h 0.08 L/kg/h 0.7 L/kg/h.
Adverse Effects
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Toxicity
=62.4 mg/kg (rat, oral).
Symptoms of overdose include drowsiness, vomiting and abdominal pain.
Side effects are usually mild and mainly involved the GI tract.
Most common adverse
GI effect is dyspepsia (11% of patients).
May cause nausea, diarrhea, abdominal pain, constipation and flatulence in greater than 3% of patients.