CALCIUM API

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways.

The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions.

Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin.

Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.

Low calcium intake may also be a risk factor in the development of osteoporosis.

The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate.

Calcium gluconate and calcium lactate are absorbed well by pregnant women.

Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways.

It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.

Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell.

It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization.

Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples.

Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

L-type calcium channel subunit alpha-1C Ligand Calcium-transporting ATPase type 2C member 1 Agonist Troponin C, skeletal muscle Agonist + 1 more target.

The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.

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Administration of calcium acetate in excess of the appropriate daily dosage may result in hypercalcemia.

Patients with hypercalcemia.

The recommended initial dose of calcium acetate for the adult dialysis patient is 2 capsules with each meal.

Increase the dose gradually to lower serum phosphorus levels to the target range, as long as hypercalcemia does not develop.

Most patients require 3-4 capsules with each meal.

Starting dose is 2 capsules with each meal.

Titrate the dose every 2-3 weeks until acceptable serum phosphorus level is reached.

Each capsule is of size ‘00el’ hard gelatin capsule shell with blue opaque cap and white opaque body imprinted with “667 mg” on cap and “IG 377” on body in black ink filled with white to off white powder.

Supplied in

Bottles of 60 (NDC 69097-862-03) and 200 (NDC 69097-862-83).

Store at 20° to 25°C (68° to 77°F) .

Calcium acetate capsules contain calcium acetate.

Animal reproduction studies have not been conducted with calcium acetate, and there are no adequate and well controlled studies of calcium acetate use in pregnant women.

Patients with end stage renal disease may develop hypercalcemia with calcium acetate treatment.

Maintenance of normal serum calcium levels is important for maternal and fetal well being.

Hypercalcemia during pregnancy may increase the risk for maternal and neonatal complications such as stillbirth, preterm delivery, and neonatal hypocalcemia and hypoparathyroidism.

Calcium acetate treatment, as recommended, is not expected to harm a fetus if maternal calcium levels are properly monitored during and following treatment.

A calcium acetate capsule contains calcium acetate and is excreted in human milk.

Human milk feeding by a mother receiving calcium acetate is not expected to harm an infant, provided maternal serum calcium levels are appropriately monitored.

Safety and effectiveness in pediatric patients have not been established.

Clinical studies of calcium acetate did not include sufficient numbers of subjects aged and over to determine whether they respond differently from younger subjects.

Other clinical experience has not identified differences in responses between elderly and younger patients.

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.