OVESTIN

ASPEN PHARMACARE AUSTRALIA
Identification
- Active ingredient (INN)
- ESTRIOL
- Internal code
- 09 G 085
- Country of Origin
- Australia
- Pharmaceutical form
- Tablet
- Prescription List
- Regulated (List II)
- Packaging
- boite de 30

DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position.
Estriol is a major urinary estrogen.
During pregnancy, large amount of estriol is produced by the placenta.
Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.
It is however available in the United States by prescription filled only by compounding pharmacies.
It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Indications
Used as a test to determine the general health of an unborn fetus.
Pharmacodynamics
Estriol (also oestriol) is one of the three main estrogens produced by the human body.
It is only produced in significant amounts during pregnancy as it is made by the placenta.
In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Metabolism
Hover over products below to view reaction partners Estriol Estriol-16-Glucuronide Estriol-17-glucuronide Estriol-3-glucuronide 16-alpha,17-beta-estriol 17-beta-D-glucuronide Estriol 3-sulfate 16-glucuronide.
Adverse Effects
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Toxicity
(LD50): Acute: >2000 mg/kg.
Warnings
For external use only.
Keep out of reach of children.Avoid contact with eyes.