AMPHONEX
BAHARAT SERUMS AND VACCINES
Identification
- Active ingredient (INN)
- AMPHOTERICINE B
- Internal code
- 13 R 505
- Country of Origin
- India
- Pharmaceutical form
- Powder for Perfusion
- Prescription List
- Highly Regulated (List I)
- Packaging
- b/1 flc
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
B shows a high order of in vitro activity against many species of fungi.
Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03-1.0 mcg/mL in vitro.
While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible.
Pseudallescheria boydii and
Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indications
Used to treat potentially life threatening fungal infections.
Pharmacodynamics
B shows a high order of in vitro activity against many species of fungi.
Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03-1.0 mcg/mL in vitro.
While Candida albicans is generally quite susceptible to amphotericin B, non.
- albicans species may be less susceptible.
Pseudallescheria boydii and
Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Absorption
Bioavailability is 100% for intravenous infusion.
Half-life
An elimination half-life of approximately 15 days follows an initial plasma half-life of about 24 hours.
Adverse Effects
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Toxicity
Oral, rat: LD 50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.