CIPROFLOXACINE BEKER

connective tissue disorders Lactation Aneurysm, family history (d') Aortic aneurysm Bradycardia Cardiopathies Gonococcal cervicitis Diabetes Passenger's diarrhoea Aortic dissection Infectious endocarditis Female Solid organ registry, background Pregnancy Hypertension Hypokalaemia Hypomagnesaemia Myocardial infarction Pseudomonas infection Streptococcal infection High gynecological infection Intra-abdominal infection Nosocomial infection Osteoarticular infection Gram-positive or anaerobic germ infection Severe infection Staphylococcal infection Urinary infection Heart failure Renal impairment Behçet's disease Coal disease Myasthenia Orchi-epididymitis Patients with swallowing difficulties Hospitalized patient Transplanted patient Rheumatoid arthritis Severe reaction due to quinolones, history (de) Elderly Subject at risk of QT space prolongation Subject at risk of aortic aneurysm or aortic dissection Subject at risk of cardiac arrhythmia Subject at risk of heart valve failure Subject at risk of seizure Subject under 18 Turner's syndrome Congenital long QT syndrome Tendinopathy due to fluoroquinolone, antecedent (de) Corticosteroid treatment in progress Extended treatment Hydroelectrolytic disorder Gonococcal urethritis Cardiac valvulopathy.

Mechanism of action

Ciprofloxacin is an antibiotic belonging to the fluoroquinolones group.

Its bactericidal activity results from inhibition of type II topo-isomerase (DNA-gyrase) and topo-isomerase Intravenous, necessary for replication, transcription, repair and recombination of bacterial DNA (deoxyribonucleic acid).

Critical concentrations separate the sensitive strains of intermediate susceptibility strains, and these strains, from the resistant ones: enterobacteria: S 1 mg/l, Pseudomonas: S 1 mg/l, Acinetobacter: S 1 mg/l, Spercneros: S 1 mg/l, Hæmophylus influentizæ and Moraxppsella scarrhalis: S 0.5 mg/l, Spercneros: S <= 1 mg/l, Spercneros: Sper: Sper.

• Alkaline phosphates (increase) (Uncommon)
• Eosinophilia (Uncommon)
• Bilirubinaemia (abnormality) (Uncommon)
• Transaminases (increase) (Uncommon)
• Hyperbilirubinaemia (Uncommon)
• Bilirubinaemia (increase) (Uncommon)
• Hypoglycaemia (Rare)
• Hyperglycaemia (Rare)
• Leucocytosis (Rare)
• Cristalluria (Rare)
• Amylasemia (increase) (Rare)
• Prothrombin (modification) (Rare)
• Neutropenia (Rare)
• INR (increase)
• Urticaria (Uncommon)
• Rash (Uncommon)
• Pruritus (Uncommon)
• Stevens-Johnson Syndrome (Very rare)
• Erythema noise (Very rare)
• Hypersudation (Rare)
• Pétechie (Very rare)
• Lyell's syndrome (Very rare)
• Polymorphic Erythema (Very rare)
• Hyperhidrosis (Rare)
• Photosensitivity (Rare)
• Generalised acute exanthemous pusulosis
• Pain in the extremities (Uncommon)
• Chest pain (Uncommon)
• Fever (Uncommon)
• Asthenia (Uncommon)
• Edema (Rare)
• Fatigue Inappropriate antidiuretic hormone secretion syndrome (IADH)
• Agranulocytosis (Very rare)
• Thrombocytopenia (Rare)
• Haemolytic anaemia (Very rare)
• Cardiac aplasia (Very rare)
• Anemia (Rare)
• Leucopenia (Rare)
• Pancytopenia (Very rare)
• Thrombocytosis (Rare)
• Liver necrosis (Very rare)
• Hepatic impairment (Rare)
• Cholestatic Ictery (Rare)
• Hepatitis (Rare)
• Oedema of Quincke (Rare)
• Hypersensitivity (Rare)
• Allergic edema (Rare)
• Serum disease (Very rare)
• Anaphylactic reaction (Very rare)
• Serum disease-like reaction (Very rare)
• Anaphylactic shock (Very rare)
• DRESS syndrome Fungal overinfection (Uncommon)
• Overinfection (Uncommon)
• Anorexia (Uncommon)
• Appetite decreased (Uncommon)
• Diplopia (Rare)
• Vision disorder (Rare)
• Dyschromatopsia (Very rare)
• Dysgueusia (Uncommon)
• Feeling dizzy (Uncommon)
• Hearing acuity (amendment) (Rare)
• Hypoacoustic (Rare)
• Tinnitus (Rare)
• Vertigo (Rare)
• Odorat (amendment) (Very rare)
• Deafness (Rare)
• Agitation (Uncommon)
• Sleep disorder (Uncommon)
• Mental confusion (Rare)
• Anxiety (Rare)
• Psychosis (Very rare)
• Temporospatial disorientation (Rare)
• Psychotic episode (Very rare)
• Depression (Rare)
• Attempted suicide (Rare)
• Abnormal dreams (Rare)
• Hallucination (Rare)
• Suicide Manic access Suicidal ideation Hypomaniac access Vasculitis (Very rare)
• Syncope (Rare)
• Vasodilatation (Rare)
• Hypotension (Rare)
• Tachycardia (Rare)
• Aortic rupture Mitral impairment
• Arrhythmia Ventricular arrhythmia Aneurysm failure Mitral regurgitation QT space extension
• Aortic aneurysm Torsades de pointes Aortic regurgitation Aortic valve failure Aortic dissection
• Vomiting (Uncommon)
• Dyspepsia (Uncommon)
• Nausea (Common)
• Abdominal pain (Uncommon)
• Diarrhoea (Common)
• Flatulence (Uncommon)
• Collision (Rare)
• Pseudomembranous colitis (Rare)
• Pancreatitis (Very rare)
• Antibiotic-related colitis (Rare)
• Joint pain (Uncommon)
• Musculoskeletal pain (Uncommon)
• Sleeping (Uncommon)
• Cramp (Rare)
• Strand cut (Very rare)
• Tendinitis (Very rare)
• Muscle pain (Rare)
• Muscle weakness (Very rare)
• Arthritis (Rare)
• Muscle hypertonia (Rare)
• Arthropathy Psychomotor hyperactivity (Uncommon)
• Headache (Uncommon)
• Hyperactivity (Uncommon)
• Brain Pseudomeur (Very rare)
• Dysesthesia (Rare)
• Intracranial hypertension (Very rare)
• Trembling (Rare)
• Hypoesthesia (Rare)
• Ataxia (Very rare)
• Convulsions (Rare)
• Walking disorder (Very rare)
• Paraesthesia (Rare)
• Myasthenia (aggravation) (Very rare)
• Migraine (Very rare)
• Epileptic disease (Rare)
• Polyneuropathy Hypoglycemic coma Memory Disorder Peripheral neuropathy Dyspnoea (Rare)
• Asthma (Rare)
• Renal impairment (Uncommon)
• Renal impairment (Uncommon)
• Tubulo-interstitial nephropathy (Rare)
• Haematuria (Rare).