APAISA BEBE

Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.

Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 2.

Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing.

Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.

Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 3.

Dexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as Panthenol.

While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.

Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus.

Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus.

This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy).

Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups.

The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline.

Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine.

Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.

Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.

Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 2.

Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.

Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 3.

Dexpanthenol is soluble in water and alcohol, although insoluble in fats and oil based substances.

With the appropriate vehicle, Dexpanthenol is easily penetrated into the skin.

Rate of penetration and absorption is reduced when Dexpanthenol is administered as an oil/water formula.

Dexpanthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A. Highest concentrations are found in the liver, adrenal glands, heart, and kidneys.

Dexpanthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A. Hover over products below to view reaction partners Dexpanthenol Pantothenic acid.

Milk of nursing mothers receiving a normal diet contains about 2 ug of pantothenic acid per mL.

About 70% of an oral dose of pantothenic acid is excreted unchanged in urine and about 30% in feces.

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Anaphylactogenesis may occur with parenteral thiamine.

Use with caution.

An intradermal test dose is recommended prior to administration in patients suspected of being sensitive to the drug.

Sensitivity to the ingredients listed.

Usually 0.25 to 2 mL by intramuscular or slow intravenous injection.

High concentrations given intravenously may be diluted using parenteral infusion solutions.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit [

B-Complex 100 Injection is available in a 30 mL multiple-dose vial individually boxed.

Phase separation due to reduced solubility can occur under certain conditions of shipping or storage (e.g. accidental freezing), which may produce visible particles.

Do not use product if these do not redissolve on warming to body temperature and shaking well.

Refrigeration of the product may cause darkening of the solution due to the riboflavin content.

The colour does not affect the safety or efficacy of the product.

Store in carton until contents are used.

Store under refrigeration 2° to 8°C (36° to 46°F).

Do not permit to freeze.

Manufactured for

Mylan Institutional LLC Morgantown, WV 26505 U.S.A.