BIOTRETANE

Alcoholism History of alcoholism History of depression Diabetes Child under 15 years of age Female likely to be pregnant Male of childbearing age Patient at risk of vascular disease Extended treatment Repeated treatment Lipid metabolism disorder Eye disorder.

Mechanism of action

Acitretin is an aromatic analogue for retinoic acid synthesis.

Clinical studies have confirmed that in psoriasis and in keratinization disorders, acitretin normalizes the processes of cell proliferation, differentiation and keratinization of the epidermis.

Its action is purely symptomatic.

Its mode of action is still poorly clarified.

• Alkaline phosphates (increase)
• Hypercholesterolaemia Transaminases (increase)
• Hypertriglyceridaemia
• Alopecia (Common)
• Hypersudation (Common)
• Mucosal dryness (Common)
• Mucite (Very common)
• Skin Fragility (Common)
• Rhagade (Very common)
• Pruritus (Very common)
• Perionyxis (Common)
• Abnormal texture of hair or hair (Common)
• Bully dermatosis (Uncommon)
• Skin desquamation (Very common)
• Dermatitis (Common)
• Fragility of nail (Common)
• Skin Erythema (Occasional)
• Photosensitivity (Rare)
• Skin atrophy Psoriasis (aggravation)
• Exfoliative dermatitis Urticaria Peripheral edema (Occasional)
• Vulkovaginitis (Rare)
• Ictery (Rare)
• Hepatitis (Rare)
• Oedema of Quincke Hypersensitivity
• Polydipsy (Very common)
• Hypervitaminosis A Glucose tolerance Blurty vision (Uncommon)
• Tolerance to contact lenses (Very common)
• Conjunctivitis (Common)
• Ulcerative keratitis (Very rare)
• Lacrymal hyposecretion (Occasional)
• Hemeralopia (Occasional)
• Madarosis Vertigo (Uncommon)
• Hyposialia (Very common)
• Cheilite (Very common)
• Labial dryness (Very common)
• Rhinite (Occasional)
• Stomatitis (Occasional)
• Dysgueusia (Occasional)
• Epistaxis (Occasional)
• Gingivite (Occasional)
• Tinnitus Hypoacoustic Dysphony Hair Leak Syndrome Botriomycome Hot flash Abdominal pain (Common)
• Digestive disorder (Common)
• Diarrhoea (Common)
• Vomiting Rectorragie Nausea Exostosis (Uncommon)
• Ligamentary calcification (Uncommon)
• Hyperostosis (Uncommon)
• Joint pain (Occasional)
• Growth retardation (Occasional)
• Bone pain (Occasional)
• Muscle pain (Occasional)
• Premature bone (Rare)
• Premature welding of epiphyses Calcification of soft tissue Intracranial hypertension (Rare)
• Peripheral neuropathy (Rare)
• Headache (Occasional)
• Leukocyte activation syndrome.