BIOLECT

Lactation Pregnancy Mild to moderate hepatic impairment Patients treated with levodopa Subject under 18 Smoking.

Mechanism of action

Rasagiline has been shown to be a potent and irreversible selective inhibitor of B-MAO that may cause an increase in extracellular dopamine concentrations in the striatum.

Increased dopamine concentration and subsequent increase in dopaminergic activity are likely responsible for the beneficial effects of rasagiline observed in dopaminergic motor dysfunction models. 1-amino-indane, the main active metabolite, is not an inhibitor of B-MAO.

• Benign tumor (Uncommon)
• Skin cancer (Common)
• Melanoma (Uncommon)
• Cancer (Uncommon)
• Vesicular-bulle rash (Uncommon)
• Dermatitis (Common)
• Rash (Common)
• Irflu pseudo-influenza syndrome (Common)
• Fall (Common)
• Fever (Common)
• Hypersexuality Polyp Kyste Sexual disorder Leucopenia (Common)
• Hypersensitivity (Common)
• Weight (decrease) (Common)
• Appetite decreased (Common)
• Conjunctivitis (Common)
• Vertigo (Common)
• Oral dryness (Common)
• Rhinite (Common)
• Depression (Common)
• Mental confusion (Uncommon)
• Abnormal dreams (Common)
• Hallucination (Common)
• Compulsions
• Agitation Dopaminergic dysregulation syndrome Lethargy Psychosexual disorder Obsessive thoughts
• Impulsive behaviour Obsessive compulsive disorder Theft Dependence of the game Impulse Control Disorder
• Stereotypic Sleep attacks Compulsive procurement Kleptomanie Dermatillomania Libido (increase)
• Orthostatic hypertension (Common)
• Angor (Common)
• Malaise (Common)
• Orthostatic hypotension (Common)
• Myocardial infarction (Uncommon)
• Hypertensive crisis (Rare)
• Hypertension Abdominal pain (Common)
• Nausea (Common)
• Constipation (Common)
• Vomiting (Common)
• Flatulence (Common)
• Joint pain (Common)
• Arthritis (Common)
• Musculoskeletal pain (Common)
• Neck pain (Common)
• Cervicalgia (Common)
• Carpal canal syndrome (Common)
• Sleeping Rigidity Dyskinesia (Very common)
• Headache (Very common)
• Stroke (Uncommon)
• Balance disorder (Common)
• Dystonia (Common)
• Excessive daytime sleepiness
• Myoclonia Sleeping Somnolence Sedation Sudden sleep Hypersomnia Serotonin syndrome
• Imperative Miction (Common).