HAEMATE P
CSL BEHRING
Identification
- Active ingredient (INN)
- FACTEUR VIII / FACTEUR VON WILLBRAND
- Internal code
- 12 H 218
- Country of Origin
- Germany
- Pharmaceutical form
- Powder + Solvent for Injectable Sol. or Perf.
- Prescription List
- Highly Regulated (List I)
- Packaging
- boite de 1 flacon de poudre + 1 flacon de solvant + un dispositif de transfert 20/20
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Associated Conditions
Cardiopathies Liver Circhrosis Female likely to be pregnant Pregnancy ECOG index >= 2 Hepatic impairment Severe renal impairment: creatinine clearance = 50% Slow metabolizer of CYP2D6 Intestinal metastasis Interstitial pneumopathy Subject under 18 Subject over 55 years Smoking Treatment with NSAIDs in progress Corticosteroid treatment in progress Gastrointestinal ulcer, history (d).
Mechanism of Action
Mechanism of action
Epidermal growth factor (EGF, Epidermal Growth Factor) and its receptor (EGFR ) have been identified as important factors in the process of cell growth and proliferation of normal and cancerous cells.
EGFR activation mutation in a cancer cell is an important factor in tumour cell growth: blocking apoptosis, increasing the production of angiogenic factors and facilitating metastasis processes.
Gefitinib is a small selective inhibitory molecule of epidermal growth factor receptor tyrosine kinase.
Getifinib is effective in tumours with activating mutations of EGFR tyrosine kinase, regardless of the treatment line.
No significant clinical activity has been shown in patients with EGFR mutation-free tumours.
Adverse Effects
- (increase) (Very common)
- ASAT (increase) (Common)
- Proteinuria (Common)
- Blood creatinine (increase) (Common)
- Bilirubinaemia (increase) (Common)
- Skin reaction (Very common)
- Alopecia (Common)
- Palmoplantary Erythrodysaesthesia (Uncommon)
- Onychopathy (Common)
- Bully dermatosis (Rare)
- Toxic epidermal necrolysis Stevens-Johnson Syndrome Rash Pruritus Skin Erythema Skin crack
- Pustulous eruption Urticaria Acne Polymorphic Erythema Dry skin Asthenia (Very common)
- Fever (Common)
- Haemorrhage (Common)
- Hepatitis (Uncommon)
- Hepatic impairment (Isolated cases)
- Hypersensitivity (Common)
- Angioedema Anorexia (Very common)
- Dehydration (Common)
- Keratite (Uncommon)
- Blepharite (Common)
- Lacrymal hyposecretion (Common)
- Conjunctivitis (Common)
- Corneal erosion (Uncommon)
- Eyelash growth Oral dryness (Common)
- Stomatitis (Very common)
- Epistaxis Skin vasculitis (Rare)
- Gastrointestinal perforation (Uncommon)
- Nausea (Very common)
- Diarrhoea (Very common)
- Pancreatitis (Uncommon)
- Vomiting (Very common)
- Interstitial pneumopathy (Common)
- Cystitis (Common)
- Hemorrhagic cystitis (Rare)
- Haematuria.