BERINERT

Lactation History of heart failure History of Crohn's disease History of haemorrhagic rectocolitis Asthma Glucose-6-phosphate-dehydrogenase deficiency Dehydration Female likely to be pregnant Gastritis, history Pregnancy, first 5 months (of) Digestive haemorrhage, history Hypertension Hypertension, history Viral infection Heart failure Mild to moderate hepatic impairment Mild to moderate renal impairment Cardiovascular disease Metrorragie Newborn exposed in utero to the medicine Chronic respiratory pathology High dose treated patient Elderly Allergic Subject at risk of hyperuricaemia Low weight Subject under 18 Subject carrying intrauterine device Extended treatment Gastroduodenal ulcer, history (d) Vaccination against varicella.

Acetylsalicylic acid

Mechanism of action Acetylsalicylic acid belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs) with analgesic, antipyretic and anti-inflammatory properties.

Its mechanism of action is based on irreversible inhibition of the cyclo-oxygenase enzymes involved in prostaglandin synthesis.

Acetylsalicylic acid also inhibits platelet aggregation by blocking platelet synthesis of thromboxane A2.

• White Globules increased (Rare)
• Hypoglycaemia Bicytopenia Liver enzymes (increase)
• Longer bleeding time Neutropenia Hyperuricaemia Urticaria (Uncommon)
• Purpura (Rare)
• Lyell's syndrome (Rare)
• Polymorphic Erythema (Rare)
• Bully dermatosis (Very rare)
• Stevens-Johnson Syndrome (Rare)
• Erythema noise (Rare)
• Fixed pigmented Erythema Rash
• Exudative polymorphic Erythema Dermatosis Edema Menorrhagia (Rare)
• Haemorrhage (Common)
• Diathesis of haemorrhagic (Common)
• Thrombocytopenia (Rare)
• Cardiac aplasia (Rare)
• Agranulocytosis (Rare)
• Bone marrow failure Haemolytic anaemia Pancytopenia Haemorrhagic syndrome
• Haemolysis Iron deficiency anaemia Leucopenia Hematoma Anemia Chronic hepatitis Hepatitis
• Hepatic impairment Hepatitis Hypersensitivity (Rare)
• Angioedema (Rare)
• Allergic edema (Rare)
• Anaphylactic reaction (Rare)
• Anaphylactic shock DRESS syndrome Drop Drop crisis Rhinite (Uncommon)
• Hearing acuity (amendment)
• Tinnitus Feeling dizzy Gingivorrhagic Ear ringing Vertigo
• Hypoacoustic Oral ulceration Epistaxis Haemorrhagic vasculitis (Rare)
• Shock (Rare)
• Vasculitis Hypertension Heart failure Kounis syndrome Dyspepsia (Common)
• Nausea (Common)
• Vomiting (Common)
• Diarrhoea (Common)
• Gastrointestinal haemorrhage (Rare)
• Small intestine ulcer
• Crohn's disease (aggravation)
• Gastroduodenal ulcer (aggravation)
• Diaphragm stenosis
• Collision Ulcer of the large intestine Duodenal Ulcer Digestive perforation Gastroduodenal ulcer
• Intestinal stenosis Melena Acute Pancreatitis Constipation Erosive gastritis Occult digestive haemorrhage
• Gastric ulcer Flatulence Gastrointestinal perforation Haemorrhagic rectocolitis (aggravation)
• Digestive haemorrhage Abdominal pain Intestinal perforation Erosive duodenite Gastritis
• Hyperchlorhydride Esophagus Ulcer Hematemesis Esophagitis Gastroduodenal perforation
• Rheumatoid purpura Intracranial haemorrhage (Rare)
• Reye's syndrome (Rare)
• Headache
• Brain haemorrhage Dyspnoea (Uncommon)
• Asthma crisis (Rare)
• Bronchospasm (Rare)
• Asthma (Rare)
• Acute respiratory distress syndrome Non-cardiogenic pulmonary edema Hemospermia Renal impairment
• Urogenital haemorrhage Acute renal impairment.