CANGIN

Lactation Pregnancy Hepatic impairment

Infant under 1 year of age Associated severe pathology Elderly Allergic.

Mechanism of action

Caspofungin acetate is a semi-synthetic lipopeptide (echinocandine) synthesized from a glarea lozoyensis fermentation product.

Caspofungin acetate inhibits the synthesis of beta-D-glucan, an essential component of the cell wall of many filamentous fungi and yeasts.

Beta-D-glucan is not present in mammalian cells.

Caspofungin fungicide activity has been demonstrated on candida.

In vitro and in vivo studies show that exposure of aspergillus to caspofungin causes lysis and death of the ends of mycelian filaments and sites where cell growth and division occur.

• Hypercalcaemia (Uncommon)
• Hypomagnesaemia (Uncommon)
• Eosinophilia (Uncommon)
• Hyperchloraemia (Uncommon)
• Hypoproteinaemia (Uncommon)
• Hypernatraemia (Uncommon)
• Blood globinaemia (decrease) (Common)
• Hyperphosphataemia (Uncommon)
• Hypophosphataemia (Uncommon)
• White Globules decreased (Common)
• Hypochloraemia (Uncommon)
• Hyperkalaemia (Uncommon)
• Hyponatremia (Uncommon)
• Blood creatinine (increase) (Uncommon)
• Hyperglycaemia (Uncommon)
• Hypocalcaemia (Uncommon)
• Prothrombin rate (increase) (Uncommon)
• INR (increase) (Uncommon)
• Liver enzymes (increase) (Common)
• Platelet number increased (Uncommon)
• Hematocrite (decrease) (Common)
• Blood bicarbonates (decrease) (Uncommon)
• Hypoalbuminaemia (Common)
• Leucocyturia (Uncommon)
• Neutropenia (Uncommon)
• Hyperuricaemia (Uncommon)
• Decreased lymphocyte count (Uncommon)
• Urinary cylinders (Uncommon)
• Hematia in the urine present (Uncommon)
• Cep time activated (elongation) (Uncommon)
• Hypokalaemia (Common)
• Hyperbilirubinaemia (Uncommon)
• Prothrombin time increased (Uncommon)
• Proteinuria (Uncommon)
• Gamma GT (increase) (Uncommon)
• Uricemia (decrease) (Uncommon)
• White Globules increased (Uncommon)
• Platelet number decreased (Uncommon)
• Urticaria (Uncommon)
• Polymorphic Erythema (Uncommon)
• Maculopapulous eruption (Uncommon)
• Skin injury (Uncommon)
• Machinous eruption (Uncommon)
• Pruritus (Common)
• Morbilliform eruption (Uncommon)
• Erythematous rash (Uncommon)
• Rash (Common)
• Generalised pruritus (Uncommon)
• Generalised rash (Uncommon)
• Hyperhidrosis (Common)
• Skin Erythema (Common)
• Pruriginous rash (Uncommon)
• Allergic dermatitis (Uncommon)
• Toxic epidermal necrolysis Stevens-Johnson Syndrome Chest damage (Uncommon)
• Pain (Uncommon)
• Frisher (Common)
• Coldness (Uncommon)
• Peripheral edema (Uncommon)
• Pain in the extremities (Uncommon)
• Heat sensation (Uncommon)
• Edema (Uncommon)
• Face edema (Uncommon)
• Chest pain (Uncommon)
• Fever (Common)
• Fatigue (Uncommon)
• Sensation of changes in body temperature (Uncommon)
• Anemia (Uncommon)
• Leucopenia (Uncommon)
• Thrombocytopenia (Uncommon)
• Coagulopathy (Uncommon)
• Cholestasis (Uncommon)
• Hepatic impairment (Uncommon)
• Hepatomegaly (Uncommon)
• Ictery (Uncommon)
• Hepatitistoxicity (Uncommon)
• Liver disorder (Uncommon)
• Anaphylactic shock Hypersensitivity
• Injection site edema (Uncommon)
• Phlebitis at the infusion site (Uncommon)
• Erythema at the infusion site (Uncommon)
• Skin rash at injection site (Uncommon)
• Infusion site induration (Uncommon)
• Irritation at the infusion site (Uncommon)
• Urticaria at the infusion site (Uncommon)
• Extravasation at the injection site (Uncommon)
• Swelling at the infusion site (Uncommon)
• Pruritus at the infusion site (Common)
• Infusion site pain (Uncommon)
• Abnormal chest X-ray Burning sensation at the injection site Injection site sensitivity
• Anorexia (Uncommon)
• Water poisoning (Uncommon)
• Metabolic acidosis (Uncommon)
• Dysphagia (Uncommon)
• Hydroelectrolytic disorder (Uncommon)
• Blurty vision (Uncommon)
• Lacrimal hypersecretion (Uncommon)
• Scleral Ictery (Uncommon)
• Palpebral edema (Uncommon)
• Hyposialia (Uncommon)
• Dysgueusia (Uncommon)
• Nasal congestion (Uncommon)
• Feeling dizzy (Uncommon)
• Pharyngo-laryngyngeal pain (Uncommon)
• Temporospatial disorientation (Uncommon)
• Insomnia (Uncommon)
• Anxiety (Uncommon)
• Congestive puff (Uncommon)
• Hypotension (Uncommon)
• Hypertension (Uncommon)
• Palpitation (Uncommon)
• Atrial fibrillation (Uncommon)
• Hot flash (Uncommon)
• Tachycardia (Uncommon)
• Arrhythmia (Uncommon)
• Thrombophlebitis (Uncommon)
• Malaise (Uncommon)
• Phlebitis (Common)
• Congestive heart failure (Uncommon)
• Upper abdominal pain (Uncommon)
• Constipation (Uncommon)
• Gastric gastric gastric gastric (Uncommon)
• Ball-down (Uncommon)
• Dyspepsia (Uncommon)
• Nausea (Common)
• Vomiting (Common)
• Abdominal pain (Uncommon)
• Diarrhoea (Common)
• Ascite (Uncommon)
• Flatulence (Uncommon)
• Lumbar pain (Uncommon)
• Muscle weakness (Uncommon)
• Bone pain (Uncommon)
• Joint pain (Common)
• Muscle pain (Uncommon)
• Headache (Common)
• Somnolence (Uncommon)
• Paraesthesia (Uncommon)
• Trembling (Uncommon)
• Hypoesthesia (Uncommon)
• Carbon dioxide (decrease) (Uncommon)
• Tachypnea (Uncommon)
• Cough (Uncommon)
• Abnormal respiratory bruises (Uncommon)
• Dyspnoea (Common)
• Paroxystic dyspnoea (Uncommon)
• Hypoxia (Uncommon)
• Rails (Uncommon)
• Bronchospasm (Uncommon)
• Respiratory squeezing (Uncommon)
• Acute respiratory distress syndrome Pulmonary edema Renal impairment (Uncommon)
• Acute renal impairment (Uncommon)
• Urinary PH (increase) (Uncommon)
• Microscopic haematuria (Uncommon).