VILDAMETFOR
EL KENDI DU MEDICAMENT
Identification
- Active ingredient (INN)
- VIDAGLIPTINE/METFORMINE CHLORHYDRATE
- Internal code
- 14 A 360
- Country of Origin
- Algeria
- Pharmaceutical form
- Film-coated Tablet
- Prescription List
- Highly Regulated (List I)
- Packaging
- b/30
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Associated Conditions
Diabetes ketoacidosis History of pancreatitis
Combination with a sulphonylurea Insulin-dependent diabetes Severe hepatitis Heart failure Hepatic impairment Moderate to severe renal impairment Hemodialysis patient Subject under 18 Serum transaminases > 3 times the normal upper limit.
Mechanism of Action
Mechanism of action
Vildagliptin, via a potent and selective inhibitory effect of DPP-4, amplifies the incretin effect on the Langerhans islets.
Vildagliptin administration results in a rapid and complete inhibition of the activity of DPP-4, resulting in an increase in the endogenous fasting and postprandial levels of the GLP-1 (glucagon -like peptide 1) and GIP (glucose -dependent insulintropic polypeptide) hormones.
By increasing endogenous levels of these hormones incretins, vildagliptin improves the sensitivity of beta cells to glucose, thereby improving insulin glucose-dependent secretion.
By increasing endogenous concentrations of
GLP-1, vildagliptin also improves the sensitivity of alpha cells to glucose, which induces a more appropriate secretion of glucose-dependent glucagon.
In the case of hyperglycaemia, this improvement in the hepatic ratio of glucose-related factors, the insulin/glucosergic mechanisms increase the insulin/glucose agent, which causes the insulin/glucose agent to decrease the insulin/glucose agent to the insulin ratio.
Adverse Effects
- Hypoglycaemia (Uncommon)
- Liver status (abnormality) (Uncommon)
- Glycaemia decreased (Common)
- ASAT (increase)
- ALT (increase)
- Pruritus (Common)
- Urticaria (Uncommon)
- Dermatitis (Common)
- Hyperhidrosis (Common)
- Rash (Common)
- Exfoliative dermatitis Bully dermatosis Bully pemphigoid
- Frisher (Uncommon)
- Asthenia (Common)
- Fatigue (Uncommon)
- Peripheral edema (Common)
- Hepatitis Hepatitis Angioedema (Rare)
- Weight (increase) (Uncommon)
- Blurty vision (Common)
- Rhinophyryngitis (Very common)
- Feeling dizzy (Common)
- Skin vasculitis Abdominal pain (Common)
- Gastroesophageal reflux (Common)
- Diarrhoea (Common)
- Nausea (Common)
- Flatulence (Uncommon)
- Constipation (Common)
- Vomiting (Common)
- Pancreatitis (Rare)
- Abnormal liver function (Rare)
- Joint pain (Common)
- Muscle pain (Common)
- Headache (Common)
- Trembling (Common)
- Upper respiratory tract infection (Common)
- Erection disorder (Uncommon).