MENOPUR
FERRING
Identification
- Active ingredient (INN)
- MENOTROPINE OU HORMONE GONADOTROPHINE POST MENOPAUSIQUE HUMAINE HMG EXPRIME EN HORMONE FOLLICULOSTIMULANTE FSH/HORMONE LUTEINISANTE LH
- Internal code
- 09 J 046
- Country of Origin
- France
- Pharmaceutical form
- Powder + Solvent
- Prescription List
- Highly Regulated (List I)
- Packaging
- b/05fl. de pdre. + 05 ampoule. de solvt. de 1ml
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH).
It is a synthetic decapeptide prepared using solid phase peptide synthesis.
GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.
Indications
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Pharmacodynamics
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
The pulsatility of
GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function.
Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.
Its short half life requires infusion pumps for its clinical use.
Mechanism of Action
Gonadotropin-releasing hormone receptor Agonist
Putative gonadotropin-releasing hormone II receptor Agonist.
Half-life
Very short, initial, 2-10 minutes; terminal, 10-40 minutes.
Adverse Effects
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