RAZIFOLINE
FRATER RAZES FORME SECHE
Identification
- Active ingredient (INN)
- FOLINATE DE CALCIUM (ACIDE FOLINIQUE)
- Internal code
- 05 H 132
- Country of Origin
- Algeria
- Pharmaceutical form
- Injection
- Prescription List
- OTC
- Packaging
- boite de 05 ampoule de 5ml (50mg/5ml) et boite de 05 ampoule de 10 ml (100mg/10ml)
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Associated Conditions
Child under 15 years of age High dose treated patient Radiotherapy, recent history (de) Elderly Gastrointestinal transit disorder Vomiting during methotrexate treatment.
Mechanism of Action
The foliar acid is a racemic mixture of dextrogyre and levogyre derivatives.
The calcium levofolinate is the levogyre (L), active form of the raceminque DL-folinic acid.
A dose of L isomer is equal to half of the dose of the racemique DL.
The efficacy and adverse effects of the L isomer are identical to those of the racemique compound.
The calcium levofolinate is frequently used to reduce toxicity and counteract the action of folate antagonists, such as the calcium methotrexate.
The calcium levofolinate and the antagonists of the folate are the same vector of transport of the fots and enter into competition for the transport of the fots.
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Adverse Effects
- Hyperammonaemia Palmoplantary Erythrodysaesthesia (Common)
- Mucite (Very common)
- Urticaria
- Toxic epidermal necrolysis Stevens-Johnson Syndrome Fever Cardiac aplasia (Very common)
- Bone marrow failure (Very common)
- Anaphylactoid reaction Anaphylactic reaction Hypersensitivity
- Dehydration (Very common)
- Stomatitis (Very common)
- Cheilite (Very common)
- Insomnia
- Depression Agitation Nausea (Very common)
- Diarrhoea (Very common)
- Vomiting (Very common)
- Digestive disorder Epilepsy (aggravation).