SYNTHOL GEL

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.

Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration.

Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations.

Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.

Menthol induces a cooling sensation on the skin upon inhalation, oral ingestion, or topical application by stimulating the cold-sensitive receptors expressed on the skin, without actually causing a drop in the skin temperature.

Menthol primarily activates the cold-sensitive

TRPM8 receptors in the skin.

Menthol, after topical application, causes a feeling of coolness due to stimulation of'cold'receptors by inhibiting Ca++ currents of neuronal membranes.

It may also yield analgesic properties via kappa-opioid receptor agonism.

Transient receptor potential cation channel subfamily M member 8 inducer Humans A Transient receptor potential cation channel subfamily A member 1 inhibitor inducer Humans A Transient receptor potential cation channel subfamily V member 3 inducer Humans A Voltage-dependent L-type calcium channel antagonist Humans U Kappa-type opioid receptor agonist Humans.

Hover over products below to view reaction partners Levomenthol p-Menthane-3,-8-diol.

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Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg, 3100 mg/kg.

DERMAL (LD50): Acute: 5001 mg/kg Rabbit.

FOR EXTERNAL USE ONLY When using this product Use only as directed Do not get into eyes or on mucous membranes Do not apply to wounds, damaged or irritated skin Do not bandage or cover with any type of wrap except clothing Do not use with a heating pad or apply external heat Do not use 1 hour prior to bathing or within 30 minutes after bathing Stop use and ask a doctor if Condition worsens Severe skin irritation occurs Pain persists for more than 7 days Symptoms clear up and occur again within a few days If pregnant or breast-feeding, or if you have sensitive skin, ask a healthcare professional before use.

Keep out of reach of children.

If swallowed, get medical help or contact Poison Control Center right away.

Adults and children 12 years and over apply to affected area; change patch to 2 times daily Children under 12 years, consult doctor before use How to apply: Clean and dry affected area Cut open pouch and remove patch Remove protective film and apply directly to area of pain Apply to affected area not more than 3 times daily Wash hands with soap after applying patch Reseal pouch containing unused patches.

This product may cause allergic reaction on some individuals.

Store in cool dry place away from direct sunlight.