SUPERSTAT PLUS

History of hepatopathies History of myopathy

History of acquired myopathy due to statin or fibrate Family history of myopathy Significant alcohol consumption KPC > 5 times the normal upper limit Child under 6 years of age Uncontrolled epilepsy Hypotension Hypothyroidism Severe acute infection Renal impairment: creatinine clearance < 60 ml/min Major surgery Myasthenia Endocrine pathology Patient at risk for diabetes High dose treated patient Genetic polymorphism Subject at risk of rhabdomyolysis Asian subject Subject over 70 years Subject with intense sporting activity Nephrotic syndrome Extended treatment Trauma Hydroelectrolytic disorder Metabolic disorder.

Mechanism of action

Rosuvastatin is a selective and competitive inhibitor of HMG Co-A reductase, an enzyme responsible for controlling the transformation of 3-hydroxy-3-methylglutaryl coenzyme A into mevalonate, a precursor of cholesterol.

The main site of action for rosuvastatin is the liver, the target organ for cholesterol lowering.

Rosuvastatin increases the number of

LDL receptors ( Low-Density Lipoprotein) on the hepatocyte surface, increasing the uptake of LDL cholesterol, and strengthening its catabolism and inhibiting hepatic synthesis of VLDL (Very Low-Density Lipoprotein), thereby reducing the number of VLDL and LDL particles.

• Transaminases (increase) (Rare)
• Proteinuria KPC (increase)
• Urticaria (Uncommon)
• Rash (Uncommon)
• Pruritus (Uncommon)
• Stevens-Johnson Syndrome Asthenia (Common)
• Edema Sexual disorder
• Gynecomastia (Very rare)
• Thrombocytopenia (Rare)
• Hepatitis (Very rare)
• Ictery (Very rare)
• Acute hepatitis Hypersensitivity (Rare)
• Lupic syndrome (Rare)
• Angioedema DRESS syndrome
• Non-insulin-dependent diabetes (Common)
• Feeling dizzy (Common)
• Depression Nightmare
• Sleep disorder Insomnia Abdominal pain (Common)
• Nausea (Common)
• Constipation (Common)
• Pancreatitis (Rare)
• Diarrhoea Muscle pain (Common)
• Myopathy (Rare)
• Muscle loss (Rare)
• Rhabdomyolysis (Rare)
• Joint pain (Very rare)
• Tendinopathy Strand cut Immune-mediated necrotic myopathy
• Myositis Headache (Common)
• Memory loss (Very rare)
• Polyneuropathy (Very rare)
• Myasthenia
• Myasthenia eye Peripheral neuropathy Interstitial pneumopathy (Exceptional)
• Cough
• Dyspnoea Haematuria (Very rare)
• Renal disorder Acute renal impairment.