CNASHighly Regulated (List I)NOROFLOX
HUPP
Identification
- Active ingredient (INN)
- NORFLOXACINE
- Internal code
- 17 D 029
- Country of Origin
- Algeria
- Pharmaceutical form
- Eye Drops Solution
- Prescription List
- Highly Regulated (List I)
- Packaging
- flacon/5ml
CNASDAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria.
Norfloxacin inhibits bacterial
DNA gyrase.
Indications
For the treatment of urinary tract infection
Pharmacodynamics
Norfloxacin is a quinolone/fluoroquinolone antibiotic.
Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.
Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Mechanism of Action
gyrase subunit A (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)) Inhibitor DNA topoisomerase 4 subunit A (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)) Inhibitor.
Route of Elimination
Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion.
It is expected to undergo both glomerular filtration and tubular secretion during renal excretion, as shown by its high renal clearance rate of approximately 275 mL/min.
Adverse Effects
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