EAU OXYGENEE 10V
LABIOCO
Identification
- Active ingredient (INN)
- PEROXYDE D'HYDROGENE
- Internal code
- 26 B 015
- Country of Origin
- Algeria
- Pharmaceutical form
- External Use Solution
- Prescription List
- OTC
- Packaging
- flacon./1l

DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2.
Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution.
If heated to its boiling point, it may undergo potentially explosive thermal decomposition.
Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction 4.
As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells 4.
Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide 1.
It is used in industrial and cosmetic applications as a bleaching agent.
Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA 4; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks.
Indications
Indicated to be used as a disinfectant and sterilizer.
Pharmacodynamics
Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts.
It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation.
Mechanism of Action
The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide.
Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo 2.
The oxidizing radical as the ferryl radical induces DNA oxidation 2.
Tyrosine-protein phosphatase non-receptor type 1 inhibitor Humans.
Absorption
It is reported that hydrogen peroxide is decomposed before absorption in the intestine.
Solutions of hydrogen peroxide displays poor penetration when applied to tissue 4.
Volume of Distribution
Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney 4.
Metabolism
Hydrogen peroxide is reduced by glutathione peroxidase, which is an endogenous enzyme in human tissue.
It is rapidly decomposed to oxygen and water when in contact with catalase, an enzyme found in blood and most tissues 4.
Hover over products below to view reaction partners Hydrogen peroxide Oxygen + Water.
Adverse Effects
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Toxicity
LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig.
LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours MSDS.
Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans.
Inhalation of highly concentrated vapours causes extreme irritation of nose and throat 4.
Hydrogen peroxide has no known carcinogenic potential.
It was shown to be mutagenic to bacteria ( Salmonella typhimurium ) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli 4.
It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro 4.