REBIF
MERCK
Identification
- Active ingredient (INN)
- INTERFERON BETA 1A
- Internal code
- 15 G 078
- Country of Origin
- United Kingdom
- Pharmaceutical form
- SC Injectable Solution (Pre-filled Syringe)
- Prescription List
- Highly Regulated (List I)
- Packaging
- b/12 seringues preremplies de 0.5ml
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Human interferon beta (166 residues), glycosylated, MW=22.5kD.
It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced.
The amino acid sequence is identical to that of natural human interferon beta.
Indications
For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum
Pharmacodynamics
Interferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens.
This enhances the activation of
CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing.
I interferons also induce the synthesis of several key antiviral mediators including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin and neopterin.
Mechanism of Action
Interferon alpha/beta receptor 1 Agonist Interferon alpha/beta receptor 2 Agonist.
Adverse Effects
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Warnings
Stop use and ask doctor if symptoms persist more than 5 days or worsen.
If pregnant or breast-feeding ask a health professional before use.
Keep out of reach of children.
Dosage & Administration
Take 15 minutes before meals Adults and children 12 years and older 5 pellets 3 times per day Children between 12 years and 6 years of age 3 pellets 3 times per day Children under 6 years 1 pellet 3 times per day to be disoolved into a little water.