ECZECORT

This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives.

These are steroids with a structure based on a hydroxylated prostane moiety.

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease).

It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Hydrocortisone is the most important human glucocorticoid.

It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions.

Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses.

Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.

Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects.

Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid.

Glucocorticoids suppress cell-mediated immunity.

They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2.

Reduced cytokine production limits

T cell proliferation.

Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors.

This diminishes both

B cell clonal expansion and antibody synthesis.

The diminished amounts of

IL-2 also leads to fewer T lymphocyte cells being activated.

Topical corticosteroids can be absorbed from normal intact skin.

Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.

Some of the topical corticosteroids and their metabolites are also excreted into the bile.

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Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing.

For external use only

Do not use.

• in the genital area if you have a vaginal discharge.

Consult a doctor.

• for the treatment of diaper rash.

When using this product.

• avoid contact with the eyes.

• do not use more than directed unless told to do so by a doctor.

• do not put directly into the rectum by using fingers or any mechanical device or applicator Stop use and ask a doctor if.

• condition worsens symptoms persist for more than 7 days or clear up and occur again within a few days, and do not begin use of any other hydrocortisone product unless you have asked a doctor.

• rectal bleeding occurs Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

• adults and children 2 years of age and older: apply to affected area not more than to 4 times daily.

• children under 2 years of age: do not use, ask a doctor.

• when practical, clean the affected area with mild soap and warm water and rinse thoroughly.

• gently dry by patting or blotting with toilet tissue or a soft cloth before applying.

• apply to affected area not more than to 4 times daily.

• children under 12 years of age: ask a doctor.

Other information.

• store at 20-25°C (68-77°F).