TETRAMAX

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections. 8, 9 It has been proven a cost-effective alternative to treatment with minocycline with comparable safety and efficacy.

Lymecycline was initially discovered in 1961.

It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries.

Lymecycline is not marketed in the

USA, however, equivalent drugs are available, such as minocycline and tetracycline. 5, 8.

Lymecycline is used for the treatment of acne in addition to other susceptible infections; propionibacterium is often the cause of acne.

Some of the infections that can be treated with lymecycline include upper respiratory tract infections, urinary tract infections, bronchitis, chlamydial infections, and rickettsial infections.

Lymecycline, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria, treating susceptible bacterial infections.

It has been shown to be safe and effective in the treatment of moderate to severe acne.

It is important to note that like other tetracyclines, lymecycline may cause esophageal irritation and ulceration, which can be prevented by drinking adequate fluids during administration.

It also has the potential to cause photosensitivity.

Lymecycline can lead to renal tubular acidosis or hepatic toxicity.

It is not recommended to administer this drug in patients with renal disease or severe hepatic disease. 8, 9.

Small ribosomal subunit protein uS4 (Escherichia coli (strain K12)) Inhibitor.

Lymecycline is 77-88% absorbed after oral administration with a relative bioavailability of 70%.

Cmax of lymecycline is 2.1 mg/L and is achieved about 3 hours after administration.

AUC is 21.9 ± 4.3 mg-h/L.

Lymecycline is lipophilic and easily crosses the cell membrane and passively diffuses through bacterial porin channels. 3, 5 As a second-generation tetracycline, the concentration in the bile ranges from 10-25 times higher than plasma concentration. 3, 7 In general, the volume of distribution of tetracyclines ranges from 1.3–1.7 L/kg or 100–130 L.

Lymecycline is 25% eliminated in the urine.

Based on being a member of the tetracycline drug class, fecal elimination is likely another route of elimination.

The half-life of lymecycline is approximately 8 hours.

Lymecycline is partially cleared by the kidneys, like other tetracyclines.

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The oral

LD50 of lymecycline in rats is 3200 mg/kg.

Overdoses with lymecycline are rare.

In the case of an overdose, gastric lavage should be performed immediately.