DYNASTAT
PFIZER
Identification
- Active ingredient (INN)
- PARECOXIB
- Internal code
- 04 B 071
- Country of Origin
- United Kingdom
- Pharmaceutical form
- Powder for IV/IM Injectable Sol.
- Prescription List
- Highly Regulated (List I)
- Packaging
- b/10
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Parecoxib is a water-soluble and injectable prodrug of valdecoxib.
It is marketed as Dynastat in the European Union.
Parecoxib is a
COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx).
As it is injectable, it can be used perioperatively when patients are unable to take oral medications.
It is approved through much of
Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States.
A letter of non-approval for parecoxib was issued by the FDA in 2005.
Indications
Used for short term perioperative pain control.
Metabolism
Metabolized primarily via
CYP3A4 and 2C9 to valdecoxib and propionic acid.
Half-life
minutes (parecoxib); 8 hours (valdecoxib).
Adverse Effects
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