MINOXYL

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.

For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.

Minoxidil is an

Oral effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance.

Minoxidil is also used topically to treat androgenetic alopecia.

Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds.

In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved.

The predominant site of minoxidil action is arterial.

Venodilation does not occur with minoxidil; thus, postural hypotension is unusual with its administration.

The antihypertensive activity of minoxidil is due to its sulphate metabolite, minoxidil sulfate.

ATP-sensitive inward rectifier potassium channel 1 Inducer Prostaglandin G/H synthase 1 Inducer.

Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man.

Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products.

Known metabolites exert much less pharmacologic effect than minoxidil itself.

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LD in rats has ranged from 1321-3492 mg/kg; in mice, 2456-2648 mg/kg.

For external use only.

For use by men only.

Keep away from fire or flame Do not use if.

• you are a woman.

• your amount of hair loss is different than that shown on the side of this carton or your hair loss is on the front of the scalp.

Minoxidil topical solution 5% is not intended for frontal baldness or receding hairline.

• you have no family history of hair loss.

• your hair loss is sudden and/or patchy.

• you do not know the reason for your hair loss.

• you are under 18 years of age.

Do not use on babies and children.

• your scalp is red, inflamed, infected, irritated, or painful.

• you use other medicines on the scalp Ask a doctor before use if you have heart disease When using this product.

• do not apply on other parts of the body.

• avoid contact with the eyes.

In case of accidental contact, rinse eyes with large amounts of cool tap water.

• some people have experienced changes in hair color and/or texture.

• it takes time to regrow hair.

Results may occur at 2 months with twice a day usage.

For some men, you may need to use this product for at least 4 months before you see results.

• the amount of hair regrowth is different for each person.

This product will not work for all men.

Stop use and ask a doctor if.

• chest pain, rapid heartbeat, faintness, or dizziness occurs.

• sudden, unexplained weight gain occurs.

• your hands or feet swell.

• scalp irritation or redness occurs.

• unwanted facial hair growth occurs.

• you do not see hair regrowth in 4 months May be harmful if used when pregnant or breast-feeding.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

• apply one mL with dropper 2 times a day directly onto the scalp in the hair loss area.

• using more or more often will not improve results.

• continued use is necessary to increase and keep your hair regrowth, or hair loss will begin again.

Other information.

• see hair loss pictures on side of this carton.

• before use, read all information on carton and enclosed leaflet.

• keep the carton.

It contains important information.

• hair regrowth has not been shown to last longer than 48 weeks in large clinical trials with continuous treatment with minoxidil topical solution 5% for men.

• in clinical studies with mostly white men aged 18-49 years with moderate degrees of hair loss, minoxidil topical solution 5% for men provided more hair regrowth than minoxidil topical solution 2%.

• store at 20° to 25°C (68° to 77°F).

Keep tightly closed.