ALCOOL CHIRURGICAL
PHARMAGHREB
Identification
- Active ingredient (INN)
- ALCOOL ETHYLIQUE
- Internal code
- 26 B 038
- Country of Origin
- Algeria
- Pharmaceutical form
- External Use Solution
- Prescription List
- OTC
- Packaging
- flacon./100ml
.jpg%3Fitok%3DMBwZ-cVG)
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body.
It has bactericidal activity and is used often as a topical disinfectant.
It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Indications
For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.
Pharmacodynamics
Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm.
This accounts for its bacteriocidal and antifungal action.
When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis).
Ninety to 98% of ethanol that enters the body is completely oxidized.
Ethanol is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations.
Ethanol also binds to
GABA, glycine, NMDA receptors and modulates their effects.
Ethanol is also metabolised by the hepatic enzyme alcohol dehydrogenase.
Mechanism of Action
Gamma-aminobutyric acid receptor subunit alpha-1 Agonist Glutamate receptor ionotropic, NMDA 3A Antagonist Glycine receptor subunit alpha-1 Agonist + 5 more targets.
Absorption
Rapidly absorbed.
Metabolism
Metabolized by cytochrome
P450 enzyme CYP2E1.
Hover over products below to view reaction partners Ethanol acetaldehyde Ethyl glucuronide.
Adverse Effects
Improve decision support & research outcomes With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
View sample adverse effects data in our new Data Library! See the data Improve decision support & research outcomes with our structured adverse effects data.
Toxicity
Oral, rat LD 50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.