CLOMYCINE
SAIDAL
Identification
- Active ingredient (INN)
- CHLORTETRACYCLINE
- Internal code
- 07 C 015
- Country of Origin
- Algeria
- Pharmaceutical form
- Dermal Ointment
- Prescription List
- Highly Regulated (List I)
- Packaging
- t/15g
DAWA Clinical Workbench v2.0
Information may not be accurate. Always consult a physician, pharmacist, or specialist before acting on any data shown here.
Description
Chlortetracycline is a tetracycline antibiotic, and historically the first member of this class to be identified.
It was discovered in by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbarow.
He discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained from a soil sample from a field in Missouri.
The organism was named
Streptomyces aureofaciens due to its gold-hued color.
Indications
Used in the manufacuring of medicated animal feeds Label.
Pharmacodynamics
Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction 2.
Mechanism of Action
16S ribosomal RNA (Enteric bacteria and other eubacteria) Inhibitor Small ribosomal subunit protein uS3 (Escherichia coli (strain K12)) Inhibitor Small ribosomal subunit protein uS8 (Escherichia coli (strain K12)) Inhibitor + 3 more targets.
Absorption
Chortetracycline reaches peak plasma concentation in about 3 hours 1.
Its oral bioavailability is 25-30%.
Volume of Distribution
Chlortetracycline has a volume of distribution of 100 liters 1.
Metabolism
Chlortetracycline is not known to undergo significant metabolism 1.
Route of Elimination
Chlortetracycline is mainly eliminated in feces 1.
Renal function does not appear to affect the rate of elimination.
Half-life
The half-life of
Chlortetracycline is 5.6 hours 1.
Adverse Effects
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Toxicity
The acute oral
LD50 in mice is 2314 mg/kg MSDS.The most common adverse effects of tertacylines are gastrointestinal disturbances, and staining of teeth and bone.
Some occurences of dental hypoplasia and bone deformity have been noted 2.
In pregnant women tetracyclines may produce hepatotoxicity.