SALAZA

Child under 15 years of age Pregnancy Hypovolaemia Mild to moderate hepatic impairment Mild to moderate renal impairment Pneumopathy Adverse reaction after administration of sulfasalazine, history.

Mechanism of action It has been shown that patients with HCH most at risk of developing colorectal cancer are those with an older colitis (more than eight years of evolution), extended colitis lesions (to or greater than the left colon), a primary sclerotic cholangitis associated with or a family history at the first level of colic cancer.

A meta-analysis of 9 observational studies (3 cohort studies and 6 case-control studies), including 334 cases of colorectal cancer and 140 cases of dysplasia for a total of 1932 patients with HCH, showed that the risk of colorectal cancer was approximately 50% lower in patients taking 5-aminosalicylic acid (5-ASA) on a regular basis than in those taking or not taking 5-ASA.

The reduction of the risk of colorectal cancer by 5-ASA, if confirmed, would involve both mechanisms related to the anti-inflammatory properties and intrinsic antitumor properties of the molecule.

• Amylasemia (increase) (Rare)
• Transaminases (increase) (Very rare)
• C-reactive protein (increase)
• Neutropenia Alkaline phosphates (increase)
• Eosinophilia Gamma GT (increase)
• Granulopenia
• Bilirubinaemia (increase)
• Skin Erythema (Common)
• Pruritus (Uncommon)
• Rash (Common)
• Exanthema (Very rare)
• Allergic dermatitis (Very rare)
• Polymorphic Erythema (Very rare)
• Alopecia (Very rare)
• Photosensitivity (Rare)
• Toxic epidermal necrolysis Stevens-Johnson Syndrome
• Erythematous rash Eczema Atopic dermatitis Allergic exanthema Urticaria Drug-derived fever
• Chest pain Frisher Anemia (Uncommon)
• Blood formula (abnormal) (Very rare)
• Cardiac aplasia
• Leucopenia Agranulocytosis Pancytopenia Thrombocytopenia Haematological injury Cholestatic hepatitis (Very rare)
• Hepatitis (Very rare)
• Hepatic impairment (Very rare)
• Cholestasis (Very rare)
• Erythematous lupus (Very rare)
• Hypersensitivity (Very rare)
• Lupic syndrome Anaphylactic reaction DRESS syndrome
• Tinnitus (Uncommon)
• Vertigo (Rare)
• Feeling dizzy (Rare)
• Myocarditis (Rare)
• Pericarditis (Rare)
• Abdominal distension (Common)
• Abdominal pain (Common)
• Anal fungus (Common)
• Nausea (Common)
• Anal pruritus (Common)
• Vomiting (Common)
• Rectal tenism (Common)
• Dyspepsia (Common)
• Perennial irritation (Common)
• Diarrhoea (Common)
• Flatulence (Common)
• Pancolitis (Very rare)
• Acute Pancreatitis (Rare)
• Constipation (Rare)
• Rectal tolerance Haemorrhagic rectocolitis (aggravation)
• Muscle pain (Very rare)
• Joint pain (Very rare)
• Paraesthesia (Uncommon)
• Peripheral neuropathy (Very rare)
• Headache (Rare)
• Intracranial hypertension Lung alveolite (Very rare)
• Hypersensitivity Pneumopathy (Very rare)
• Pneumopathy (Very rare)
• Pulmonary dysfunction (Very rare)
• Cough Dyspnoea Pulmonary infiltration
• Bronchospasm Pulmonary eosinophilia Cryesia Allergic alveolite Interstitial pneumopathy
• Pneumonia Urine colour (change) (Very rare)
• Renal impairment (Very rare)
• Nephrotic syndrome (Very rare)
• Oligospermie (Very rare)
• Tubulo-interstitial nephropathy (Exceptional)
• Renal impairment
• Chronic interstitial nephropathy Acute interstitial nephropathy Urinary lithiasis.