MAFEPAIN

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties.

It is an inhibitor of cyclooxygenase.

For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs).

It exhibits anti-inflammatory, analgesic, and antipyretic activities.

Similar to other

NSAIDs, mefenamic acid inhibits prostaglandin synthetase.

Mefenamic acid is rapidly absorbed after oral administration.

Mefenamic acid undergoes metabolism by

CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur.

The activity of these metabolites has not been studied.

Mefenamic acid is also glucuronidated directly.

Hover over products below to view reaction partners Mefenamic acid 3-hydroxymethyl mefenamic aci.

The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours.

Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys.

Both renal and hepatic excretion are significant pathways of elimination.

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Oral, rat LD 50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.

For external use only.

Do not use more than one acne product at a time.

After area is wet with

Blemfree™ Cleansing Wash Concentrate has foamed, tap Blemfree™ Cleansing Spheres with fingertips and massage in small circles for 60 seconds.

Proceed to rinse step.